患者病史

The patient presented with girdle-like lumbar pain 放射至右臀部和左腿背侧直至脚跟。运动时出现痉挛性疼痛。任何体位改变时, sitting or standing, the patient assumed a forced protective posture. Visual examination revealed lumbar spine curvature and pelvic misalignment.

The patient had a history of L5/S1 herniation，为此于2013年进行了射频髓核切除术。术后状况有所改善，但运动时放射性疼痛作为术后后果发展。后续保守治疗（神经根阻滞、注射、理疗）未能提供改善。did not provide lasting improvement.

诊断

Status post radiofrequency nucleotomy L5/S1 (2013) — with postoperative complications
Hypolordosis — disruption of the physiological lumbar curve
Degenerative changes and disc height reduction L4/L5
Pseudoretrolisthesis of L4 — posterior vertebral body displacement
Complete L5/S1 disc wear with bone-to-bone vertebral contact — absolute degeneration
Pseudoretrolisthesis of L5
Bilateral spondylarthrosis L4/L5 and L5/S1 — activated facet joint arthrosis
Activated osteochondrosis L4/L5 and L5/S1
Bilateral neuroforaminal stenosis L4/L5 and L5/S1
Lumbosacral destabilization
Spinal sagittal balance disruption

手术报告 — MIBRAR®方法

Procedure performed on 02.05.2016 at the MIBRAR clinic (Munich) under Prof. Dr. med. Arsen Babayan. Outpatient, under local anesthesia, with fluoroscopic guidance.

Venous blood collection from Vena cephalica — separation of autologous CGF疗法F concentrate enriched with platelets, growth factors, and anti-inflammatory factors
Liposuction — harvesting of subcutaneous adipose tissue and separation of Lipogems® concentrate with regenerative substance concentration 1000 times greater than bone marrow
Intradiscal transplantation under fluoroscopic guidance into L4/L5 and L5/S1 discs — disc height, volume, and shape reconstruction
Bilateral intra-articular transplantation into L4/L5, L5/S1 facet joints — joint space widening and joint reconstruction
Peridural application into foraminal openings with dilation and lavage of neuroforamina L4/L5 and L5/S1 bilaterally

X-ray and MRI — Before, During, and 18 Months After MIBRAR®

15张图像系列记录了L4/L5和L5/S1椎间盘的分阶段重建：从术前状况经术中结果到18个月随访。 Final images show full reconstruction of both segments and sagittal balance restoration.

Pre-operative lumbar MRI: L4/L5 degeneration, L5/S1 wear, osteochondrosis

Pre-operative MRI (sagittal plane, 3 slices): Degenerative deformation L4/L5, post-surgical L5/S1 wear with bone-to-bone contact, osteochondrosis. Sagittal balance disruption.

Lumbar MRI: coronal plane — L4/L5, L5/S1 disc degeneration, scoliosis

Pre-operative MRI (coronal plane): Degenerative deformation of L4/L5 and L5/S1 discs, bony changes, right-sided scoliosis.

Lumbar MRI: axial plane — L4/L5, L5/S1 facet joint arthrosis

Pre-operative MRI (axial plane): L4/L5 and L5/S1 facet joint arthrosis — bilateral articular surface degeneration.

X-ray: intradiscal MIBRAR® transplantation L5/S1 — sagittal and frontal views

Intraoperative X-ray (sagittal): Before surgery — retrolisthesis, disc wear. 术后即刻 MIBRAR® — disc height increase, retrolisthesis resolved, both segments reconstructed.

X-ray: frontal view — L4/L5, L5/S1 disc reconstruction during MIBRAR® procedure

Intraoperative X-ray (frontal): Left — nearly absent L5/S1 interdisc space before surgery. Right — space increase, volume restoration of both segments.

18-month follow-up X-ray: before and after comparison — full disc reconstruction

18-month follow-up (sagittal): Comparison with pre-operative condition — full reconstruction of height and shape of both discs, retrolisthesis resolved, spinal sagittal balance restored.

18-month follow-up X-ray: frontal view — L4/L5, L5/S1 segment reconstruction

18-month follow-up (frontal): Further increase in interdisc space and reconstruction of both segments compared to intraoperative result — confirmation of ongoing regeneration.

治疗结果

After 1 week

Complete absence of complaints and all previously described symptoms — girdle-like pain, leg radiation, cramping pain during movement. Pain medication discontinued.

After 18 months

Follow-up X-ray (10.11.2017) confirmed: full reconstruction of both L4/L5 and L5/S1 segments. Disc height and shape restored, retrolisthesis resolved, sagittal balance normalized. Regeneration continued after the procedure.

长期

Symptoms did not recur. The patient has no limitations in daily life, actively participates in sports. Spinal fusion and disc replacement were not required.