What is CGF

CGF (Concentrated Growth Factors) — next generation of PRP technologies. Developed by Professor Sacco (Nice, France). Difference from PRP: programmed centrifugation with variable speed creates a dense fibrin scaffold saturated with growth factors and cellular elements.

CGF Composition

Growth Factors

PDGF (platelet-derived) — cell migration and proliferation. TGF-beta — collagen and proteoglycan synthesis. VEGF — angiogenesis (new blood vessels). EGF — epithelialization. IGF-1 — cell growth and differentiation. BMP (bone morphogenetic protein) — osteogenesis.

Fibrin Scaffold

Dense three-dimensional fibrin matrix. Remains in the injury zone for weeks (PRP is absorbed in hours). Provides prolonged growth factor release. Serves as a scaffold for cell migration and attachment.

Cellular Elements

Platelets in optimal concentration. Leukocytes: neutrophils (antimicrobial protection) + monocytes/macrophages (regeneration coordination). CD34+ progenitor cells from peripheral blood.

Preparation of CGF

1. Blood Draw

20-40 ml venous blood from the cubital vein. Standard procedure, like a blood test. Special tubes without anticoagulant (glass with clotting activator).

2. Programmed Centrifugation

Unique protocol with variable rotation speed. Alternating acceleration and deceleration creates optimal fraction separation and forms a dense fibrin scaffold. Time: 12-15 minutes.

3. CGF Extraction

Fibrin clot (CGF membrane) is extracted from the tube. Can be used as gel (injection) or membrane (application). Liquid fraction (CGF serum) also contains growth factors.

CGF vs PRP — key differences

Parameter	PRP	CGF
Centrifugation	Constant speed	Variable speed (programmed)
Form	Liquid	Fibrin gel/membrane
Growth Factor Concentration	2-5x baseline blood	10x baseline blood
Scaffold	No	Yes (dense fibrin)
Duration of Action in Tissue	Hours	Weeks
Anticoagulant	Yes (sodium citrate)	No (natural clotting)
Leukocytes	Variable (system-dependent)	Optimal ratio

→ Detailed comparison of stem cells vs PRP

CGF Applications in MIBRAR®

Joints

Intra-articular injection of CGF gel for osteoarthritis, synovitis, and chondral defects. Growth factors stimulate chondrocytes, fibrin scaffold fills cartilage defects.

Intervertebral Discs

Intradiscal injection of CGF + Lipogems®. CGF provides an environment for regeneration, Lipogems® supplies stem cells for differentiation into nucleus pulposus cells.

Tendons and Ligaments

Periarticular injection of CGF for tendinopathies. Fibrin membrane serves as a scaffold for organized collagen growth. Growth factors stimulate tenocytes.

Bone

Stimulation of osteogenesis in delayed fracture consolidation, cysts, and defects. BMP in CGF activates osteoblasts.

Synergy of CGF + Lipogems®

In the MIBRAR® method, CGF and Lipogems® are used together. This is not just the sum of components — it is synergy:

CGF creates the environment

Growth factors + fibrin scaffold + antimicrobial protection = optimal environment for stem cell survival and function.

Lipogems® supplies the cells

Mesenchymal stem cells + pericytes + extracellular matrix = cellular material for true regeneration.

Result

Tissue regeneration, not just healing stimulation. Lifelong effect through complete tissue restoration. Structural changes on MRI.

→ Learn more about Lipogems® in orthopedics

We use the maximum from your blood

CGF is the foundation of MIBRAR® regenerative therapy.

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Questions about CGF

What is CGF?

Concentrated Growth Factors — concentrated growth factors from the patient's blood. Fibrin gel with growth factors 10 times higher than in PRP. Key component of the MIBRAR® method.

How does CGF differ from PRP?

CGF contains 10 times more growth factors. It has a fibrin scaffold (PRP is liquid). Acts for weeks (PRP — hours). Programmed centrifugation with variable speed.

How is CGF obtained?

From 20-40 ml of the patient's venous blood. Programmed centrifugation (variable speed, 12-15 minutes). Extraction of the fibrin clot. Used immediately — no storage.

Is CGF safe?

Absolutely. CGF is from the patient's own blood (autologous). No risk of allergy, rejection, or infection. No chemical additives or anticoagulants.