Both methods use the patient’s own cells. But between them lies a vast gap in effectiveness. Let’s break it down why.

What is PRP?

PRP (Platelet-Rich Plasma) — blood plasma enriched with platelets. 10–20 ml of blood is drawn, centrifuged, and the resulting plasma is injected into the joint. Platelets release growth factors that stimulate healing.

What is MIBRAR®?

MIBRAR® uses two types of concentrates:

  • CGF — concentrated growth factors (5–10 times more than in PRP)
  • Lipogems® — mesenchymal stem cells from adipose tissue

Delivery is performed through a 0.3–1.5 mm micropuncture under 3D navigation with Cyber Navi Hand™.

Comparison Table

ParameterPRPMIBRAR®
Growth FactorsBasic concentration5–10 times higher (CGF)
Stem CellsNoneYes (Lipogems® MSCs)
NavigationBlind injection3D + Ultrasound navigation
Cartilage RegenerationPartialComplete (stages I–III)
Effect Duration6–12 monthsYears

Scientific Explanation of the Difference

PRP contains only platelets and their growth factors. This is sufficient to stimulate healing of soft tissues (tendons, ligaments), but insufficient for cartilage regeneration. Cartilage is avascular tissue without its own blood supply. For its restoration, the following are needed:

  • Mesenchymal stem cells — capable of differentiating into chondrocytes (PRP does not contain them)
  • High concentration of TGF-β3 — the key chondrogenic factor (in CGF it is 5-10 times higher)
  • Extracellular matrix — scaffold for cell adhesion (Lipogems® contains native matrix)

One More Critical Difference: Delivery

Most clinics administer PRP “blindly” — the needle is directed into the joint cavity without visual control. Studies show that with blind injection into the knee joint, up to 20% of injections miss the cavity. When injecting into the spine, accuracy is even more critical.